Genetic Disorders

Choose the Correct Answer

Correct Answer : Option b

Explanation
Leigh's Disease is a rare, severe neurological disorder that primarily affects the brain, but can also impact other organs and systems. The disease typically affects areas of the brain responsible for movement, coordination, and autonomic functions.

Statement 1 is correct: Leigh's disease can be caused by mutations in both mitochondrial DNA and nuclear DNA. These mutations lead to mitochondrial dysfunction, which disrupts energy production in cells and primarily affects the nervous system and other high-energy organs.

Statement 2 is not correct: While Leigh's disease can affect the heart, it is not primarily a heart disease. The disease mainly impacts the brain and central nervous system, causing neurological symptoms. Cardiac issues can be a complication, but they are not the primary manifestation.

Statement 3 is correct: Leigh's disease primarily affects the brain and central nervous system, leading to severe neurological symptoms, including problems with movement, balance, and coordination. These are key features of the disease.